Differences in breast tissue oxygenation following radiotherapy

Ken Dornfeld, Charles E. Gessert, Colleen M. Renier, David D. McNaney, Rodolfo E. Urias, Denise M. Knowles, Jean L. Beauduy, Sherry L. Widell, Bonita L. McDonald

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Tissue perfusion and oxygenation changes following radiotherapy may result from and/or contribute to the toxicity of treatment. Breast tissue oxygenation levels were determined in the treated and non-treated breast 1 year after radiotherapy for breast conserving treatment. Transcutaneous oxygenation varied between subjects in both treated and non-treated breast. Subjects without diabetes mellitus (n = 16) had an average oxygenation level of 64.8 ± 19.9 mmHg in the irradiated breast and an average of 72.3 ± 18.1 mmHg (p = 0.018) at the corresponding location in the control breast. Patients with diabetes (n = 4) showed a different oxygenation pattern, with lower oxygenation levels in control tissue and no decrease in the irradiated breast. This study suggests oxygenation levels in normal tissues vary between patients and may respond differently after radiotherapy.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalRadiotherapy and Oncology
Issue number2
StatePublished - Aug 2011


  • Breast cancer
  • Normal tissue injury
  • Radiotherapy
  • Tissue oxygenation


Dive into the research topics of 'Differences in breast tissue oxygenation following radiotherapy'. Together they form a unique fingerprint.

Cite this