Differential production of and migratory response to β chemokines by human microglia and astrocytes

P. K. Peterson, S. Hu, J. Salak-Johnson, T. W. Molitor, C. C. Chao

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

Little is known about the participation of β chemokines in inflammatory processes within the central nervous system. The release of three of these peptides (macrophage inflammatory protein [MIP]-1α, MIP-1β, and monocyte chemoattractant protein-1) from human fetal microglial cell and astrocyte cultures was assessed following stimulation by lipopolysaccharide, interleukin-1β, and tumor necrosis factor-α. Although striking differences were found between these two types of glial cells in their responsiveness to lipopolysaccharide and cytokines, both microglia and astrocytes produced all three β chemokines. Only microglial cells, however, demonstrated an increased migratory response to the β chemokines. The results of this in vitro study suggest that β chemokines may play an important role in the trafficking of mononuclear phagocytes within the brain.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalJournal of Infectious Diseases
Volume175
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

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