TY - JOUR
T1 - Differential production of and migratory response to β chemokines by human microglia and astrocytes
AU - Peterson, P. K.
AU - Hu, S.
AU - Salak-Johnson, J.
AU - Molitor, T. W.
AU - Chao, C. C.
PY - 1997
Y1 - 1997
N2 - Little is known about the participation of β chemokines in inflammatory processes within the central nervous system. The release of three of these peptides (macrophage inflammatory protein [MIP]-1α, MIP-1β, and monocyte chemoattractant protein-1) from human fetal microglial cell and astrocyte cultures was assessed following stimulation by lipopolysaccharide, interleukin-1β, and tumor necrosis factor-α. Although striking differences were found between these two types of glial cells in their responsiveness to lipopolysaccharide and cytokines, both microglia and astrocytes produced all three β chemokines. Only microglial cells, however, demonstrated an increased migratory response to the β chemokines. The results of this in vitro study suggest that β chemokines may play an important role in the trafficking of mononuclear phagocytes within the brain.
AB - Little is known about the participation of β chemokines in inflammatory processes within the central nervous system. The release of three of these peptides (macrophage inflammatory protein [MIP]-1α, MIP-1β, and monocyte chemoattractant protein-1) from human fetal microglial cell and astrocyte cultures was assessed following stimulation by lipopolysaccharide, interleukin-1β, and tumor necrosis factor-α. Although striking differences were found between these two types of glial cells in their responsiveness to lipopolysaccharide and cytokines, both microglia and astrocytes produced all three β chemokines. Only microglial cells, however, demonstrated an increased migratory response to the β chemokines. The results of this in vitro study suggest that β chemokines may play an important role in the trafficking of mononuclear phagocytes within the brain.
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U2 - 10.1093/infdis/175.2.478
DO - 10.1093/infdis/175.2.478
M3 - Article
C2 - 9203678
AN - SCOPUS:0031024047
SN - 0022-1899
VL - 175
SP - 478
EP - 481
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -