Digital necrosis in acquired immune deficiency syndrome vasculopathy treated with recombinant tissue plasminogen activator

Steve S. Roh, Elie Gertner

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Widespread digital ischemic changes and gangrene of the hands and feet is an uncommon but dramatic presentation in patients with human immunodeficiency virus (HIV) infection. We describe a patient in whom these clinical findings were associated with elevated serum endothelin levels. Because endothelin may affect the fibrinolytic system, we elected to treat with tissue plasminogen activator (tPA), which resulted in salvage of tissue of the fingers and toes. Patients with HIV infection with widespread ischemic necrosis and gangrene may require treatment with corticosteroids (in the event of possible vasculitis), thrombolytic agents (for the thrombotic component), or both, unless there are contraindications to either.

Original languageEnglish (US)
Pages (from-to)2258-2261
Number of pages4
JournalJournal of Rheumatology
Volume24
Issue number11
StatePublished - Nov 1 1997

Keywords

  • Human immunodeficiency virus
  • Necrosis
  • Plasminogen activator

Fingerprint Dive into the research topics of 'Digital necrosis in acquired immune deficiency syndrome vasculopathy treated with recombinant tissue plasminogen activator'. Together they form a unique fingerprint.

Cite this