Discriminative stimulus properties of phenytoin in the pigeon

Kathleen Krafft; James Cleary; Alan Poling

doi:10.1007/BF00433021

Discriminative stimulus properties of phenytoin in the pigeon

Kathleen Krafft, James Cleary, Alan Poling

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Abstract

Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlorpromazine, d-amphetamine, diazepam, and phenobarbital failed to produce phenytoin-like patterns of responding.

Original language	English (US)
Pages (from-to)	82-83
Number of pages	2
Journal	Psychopharmacology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1007/BF00433021
State	Published - Jan 1983
Externally published	Yes

Keywords

Chlorpromazine
Diazepam
Drugs as discriminative stimuli
Key-peck response
Phenobarbital
Phenytoin
Pigeons
d-Amphetamine

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abstract = "Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlorpromazine, d-amphetamine, diazepam, and phenobarbital failed to produce phenytoin-like patterns of responding.",

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AB - Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlorpromazine, d-amphetamine, diazepam, and phenobarbital failed to produce phenytoin-like patterns of responding.

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KW - d-Amphetamine

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Discriminative stimulus properties of phenytoin in the pigeon

Abstract

Keywords

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