TY - JOUR
T1 - Distribution coefficient of rifabutin in liposome/water system as measured by different methods
AU - Vostrikov, Vitaly V.
AU - Selishcheva, Alla A.
AU - Sorokoumova, Galina M.
AU - Shakina, Yulia N.
AU - Shvets, Vitaly I.
AU - Savel'ev, Oleg Yu
AU - Polshakov, Vladimir I.
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing 31P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.
AB - Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing 31P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.
KW - Distribution coefficient
KW - Fluorescence
KW - Liposomes
KW - P NMR
KW - Rifabutin
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U2 - 10.1016/j.ejpb.2007.05.014
DO - 10.1016/j.ejpb.2007.05.014
M3 - Article
C2 - 17614265
AN - SCOPUS:37849009597
SN - 0939-6411
VL - 68
SP - 400
EP - 405
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
IS - 2
ER -