TY - JOUR
T1 - Double-blind placebo-controlled trial of static magnets for the treatment of osteoarthritis of the knee
T2 - Results of a pilot study
AU - Wolsko, Peter M.
AU - Eisenberg, David M.
AU - Simon, Lee S.
AU - Davis, Roger B.
AU - Walleczek, Jan
AU - Mayo-Smith, Michael
AU - Kaptchuk, Ted J.
AU - Phillips, Russell S.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2004/3
Y1 - 2004/3
N2 - Context: Outpatient clinical studies of magnet therapy, a complementary therapy commonly used to treat osteoarthritis (OA), have been limited by the absence of a credible placebo control. Objective: Our objective was to assess the feasibility and promise of studying static magnetic therapy for knee OA and determine the ability of a new placebo-magnet device to provide concealment of group assignment. Design: Randomized, double-blind, placebo-controlled clinical trial. Setting: Academic teaching hospital in Boston. Participants: We enrolled 29 subjects with idiopathic or post-traumatic OA of the knee. Interventions: Subjects received either high-strength magnetic (active) or placebo-magnetic (placebo) knee sleeve treatment for 4 hours in a monitored setting and self-treatment 6 hours daily for 6 weeks. Main Outcome Measures: Primary outcomes were change in knee pain as measured by the WOMAC Osteoarthritis Index Pain Subscale at 6 weeks and extent of group concealment at study end. Results: At 4 hours, VAS pain scores (±SE) on a 5-item scale (0-500, 500 worst) decreased 79±18 mm in the active group and 10±21 mm in the placebo group (P<0.05). There were no significant differences in any primary or secondary measure of efficacy between the treatment groups at 6 weeks. Despite widespread testing for magnetic properties, at study end, 69% of the active group and 77% of the placebo group (P>0.2) believed that they had been assigned to the active treatment group. Conclusion: Despite our small sample size, magnets showed statistically significant efficacy compared to placebo after 4 hours under rigorously controlled conditions. The sustained efficacy of magnetic therapy for knee osteoarthritis could be assessed in an adequately powered trial utilizing an appropriate control such our new placebo-magnet device.
AB - Context: Outpatient clinical studies of magnet therapy, a complementary therapy commonly used to treat osteoarthritis (OA), have been limited by the absence of a credible placebo control. Objective: Our objective was to assess the feasibility and promise of studying static magnetic therapy for knee OA and determine the ability of a new placebo-magnet device to provide concealment of group assignment. Design: Randomized, double-blind, placebo-controlled clinical trial. Setting: Academic teaching hospital in Boston. Participants: We enrolled 29 subjects with idiopathic or post-traumatic OA of the knee. Interventions: Subjects received either high-strength magnetic (active) or placebo-magnetic (placebo) knee sleeve treatment for 4 hours in a monitored setting and self-treatment 6 hours daily for 6 weeks. Main Outcome Measures: Primary outcomes were change in knee pain as measured by the WOMAC Osteoarthritis Index Pain Subscale at 6 weeks and extent of group concealment at study end. Results: At 4 hours, VAS pain scores (±SE) on a 5-item scale (0-500, 500 worst) decreased 79±18 mm in the active group and 10±21 mm in the placebo group (P<0.05). There were no significant differences in any primary or secondary measure of efficacy between the treatment groups at 6 weeks. Despite widespread testing for magnetic properties, at study end, 69% of the active group and 77% of the placebo group (P>0.2) believed that they had been assigned to the active treatment group. Conclusion: Despite our small sample size, magnets showed statistically significant efficacy compared to placebo after 4 hours under rigorously controlled conditions. The sustained efficacy of magnetic therapy for knee osteoarthritis could be assessed in an adequately powered trial utilizing an appropriate control such our new placebo-magnet device.
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M3 - Article
C2 - 15055092
AN - SCOPUS:1542615137
SN - 1078-6791
VL - 10
SP - 36
EP - 43
JO - Alternative therapies in health and medicine
JF - Alternative therapies in health and medicine
IS - 2
ER -