Abstract
Dynamins and BAR proteins are crucial in a wide variety of cellular processes for their ability to mediate membrane remodeling, such as membrane curvature and membrane fission and fusion. In this review, we highlight dynamins and BAR proteins and the cellular mechanisms that are involved in the initiation and progression of cancer. We specifically discuss the roles of these proteins in endocytosis, endo-lysosomal trafficking, autophagy, and apoptosis as these processes are all tightly linked to membrane remodeling and cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 475-484 |
| Number of pages | 10 |
| Journal | Critical Reviews in Oncogenesis |
| Volume | 20 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 by Begell House, Inc.
Keywords
- BAR domain
- Cancer
- Drp1
- Dynamin
- Endophilin
- Membrane fission and fusion
- Mfn
- Opa
