Dynamins and BAR proteins—Safeguards against cancer

Anna C. Sundborger, Jenny E. Hinshaw

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Dynamins and BAR proteins are crucial in a wide variety of cellular processes for their ability to mediate membrane remodeling, such as membrane curvature and membrane fission and fusion. In this review, we highlight dynamins and BAR proteins and the cellular mechanisms that are involved in the initiation and progression of cancer. We specifically discuss the roles of these proteins in endocytosis, endo-lysosomal trafficking, autophagy, and apoptosis as these processes are all tightly linked to membrane remodeling and cancer.

Original languageEnglish (US)
Pages (from-to)475-484
Number of pages10
JournalCritical Reviews in Oncogenesis
Volume20
Issue number5-6
DOIs
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 by Begell House, Inc.

Keywords

  • BAR domain
  • Cancer
  • Drp1
  • Dynamin
  • Endophilin
  • Membrane fission and fusion
  • Mfn
  • Opa

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