Effect of age on survival between open repair and surveillance for small abdominal aortic aneurysms

Giovanni Filardo, Frank A Lederle, David J. Ballard, Cody Hamilton, Briget Da Graca, Jeph Herrin, Danielle M. Sass, Gary R. Johnson, Janet T. Powell

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Randomized controlled trials have shown no signi ficant difference in survival between immediate open repair and surveillance with selective repair for asymptomatic abdominal aortic aneurysms of 4.0 to 5.5 cm in diameter. This lack of difference has been shown to hold true for all diameters in this range, in men and women, but the question of whether patients of different ages might obtain different benefits has remained unanswered. Using the pooled patient-level data for the 2,226 patients randomized to immediate open repair or surveillance in the United Kingdom Small Aneurysm Trial (UKSAT; September 1, 1991, to July 31, 1998; follow-up 2.6 to 6.9 years) or the Aneurysm Detection and Management (ADAM) trial (August 1, 1992, to July 31, 2000; follow-up 3.5 to 8.0 years), the adjusted effect of age on survival in the 2 treatment groups was estimated using a generalized propensity approach, accounting for a comprehensive array of clinical and nonclinical risk factors. No signi ficant difference in survival between immediate open repair and surveillance was observed for patients of any age, overall (p = 0.606) or in men (p = 0.371) or women separately (p = 0.167). In conclusion, survival did not differ significantly between immediate open repair and surveillance for patients of any age, overall or in men or women. Combined with the previous evidence regarding diameter, and the lack of benefit of immediate endovascular in trials comparing it with surveillance repair for small abdominal aortic aneurysms, these results suggest that surveillance should be the first-line management strategy of choice for asymptomatic abdominal aortic aneurysms of 4.0 to 5.5 cm.

Original languageEnglish (US)
Pages (from-to)1281-1286
Number of pages6
JournalAmerican Journal of Cardiology
Volume114
Issue number8
DOIs
StatePublished - Oct 15 2014

Bibliographical note

Funding Information:
The Aneurysm Detection and Management (ADAM) study was supported by the VA Cooperative Studies Program , Department of Veterans Affairs Office of Research and Development, Washington, District of Columbia. The UK Small Aneurysm Trial (UKSAT) was funded by the Medical Research Council and British Heart Foundation ,. This work was funded by Grant R01HS018576 from the Agency for Healthcare Research and Quality , Rockville, Maryland. Additional funding was provided by the Bradley Family Endowment to Baylor Health Care System Foundation.

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'Effect of age on survival between open repair and surveillance for small abdominal aortic aneurysms'. Together they form a unique fingerprint.

Cite this