Effect of bisphosphonate use on risk of postmenopausal breast cancer: Results from the randomized clinical trials of alendronate and zoledronic acid

Trisha F. Hue, Steven R. Cummings, Jane A. Cauley, Douglas C. Bauer, Kristine E. Ensrud, Elizabeth Barrett-Connor, Dennis M. Black

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Importance: Studies have shown that bisphosphonatesmay have antitumor and antimetastatic properties. Recently, observational studies have suggested a possible protective effect of bisphosphonates on breast cancer, but the effect of bisphosphonate use on risk of breast cancer has not been tested in randomized trials.

Objective: To assess the relationship of postmenopausal breast cancer incidence and bisphosphonate use using data from 2 randomized (1:1), double-blind, placebo-controlled trials.

Design, Setting, and Participants: The Fracture Intervention Trial (FIT) randomly assigned 6459 women aged 55 to 81 years to alendronate or placebo for a mean follow-up of 3.8 years. The Health Outcomes and Reduced Incidence With Zoledronic Acid Once Yearly-Pivotal Fracture Trial (HORIZON-PFT) randomly assigned 7765 women aged 65 to 89 years to annual intravenous zoledronic acid or placebo for a mean follow-up of 2.8 years. Data were collected at clinical centers in the United States (FIT and HORIZON-PFT) and in Asia and the Pacific, Europe, North America, and South America (HORIZON-PFT).Women, in either study, with recurrent breast cancer or who reported a history of breast cancer were excluded from analyses. In each trial, a blinded review was conducted of each cancer adverse event report to verify incident invasive breast cancer cases. The primary analysis compared events in the active vs placebo group using a log-rank test.

Intervention: Alendronate vs placebo (FIT) or zoledronic acid vs placebo (HORIZON-PFT).

Main Outcomes and Measures: Hazard ratio for incident breast cancer in the bisphosphonate treatment group compared to the placebo group.

Results: There was no significant difference in the rate of breast cancer in FIT: 1.5%(n = 46) in the placebo group and 1.8%(n = 57) in the alendronate group (hazard ratio [HR], 1.24 [95% CI, 0.84-1.83]). In HORIZON-PFT, there was also no significant difference: 0.8%(n = 29) in the placebo group and 0.9%(n = 33) in the zoledronic acid group (HR, 1.15 [95%CI, 0.70-1.89]). There was also no significant difference when the data from FIT and HORIZON-PFT were pooled (HR, 1.20 [95%CI, 0.89-1.63]).

Conclusions and Relevance: These 2 randomized clinical trials do not support the findings from observational research. Contrary to the results from observational studies, we found that 3 to 4 years of bisphosphonate treatment did not decrease the risk of invasive postmenopausal breast cancer.

Original languageEnglish (US)
Pages (from-to)1550-1557
Number of pages8
JournalJAMA internal medicine
Volume174
Issue number10
DOIs
StatePublished - Oct 1 2014

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