TY - JOUR
T1 - Effect of captopril on the renin-angiotensin system in hypertensive children
AU - Friedman, Aaron L.
AU - Chesney, Russell W.
PY - 1983/11
Y1 - 1983/11
N2 - Nine patients with refractory hypertension, ranging in age from 6 to 18 years, were given captopril. The underlying cause of hypertension varied widely, but in all patients captopril produced a marked decrease in blood pressure. After treatment with captopril, patients showed an increase in plasma renin activity and plasma angiotensin I levels, with a concomitant fall in plasma angiotensin II and plasma aldosterone concentrations. Our data are similar to those reported in adults, and support the view that one mode of action of captopril is mediated via a decrease in plasma angiotensin II concentration.
AB - Nine patients with refractory hypertension, ranging in age from 6 to 18 years, were given captopril. The underlying cause of hypertension varied widely, but in all patients captopril produced a marked decrease in blood pressure. After treatment with captopril, patients showed an increase in plasma renin activity and plasma angiotensin I levels, with a concomitant fall in plasma angiotensin II and plasma aldosterone concentrations. Our data are similar to those reported in adults, and support the view that one mode of action of captopril is mediated via a decrease in plasma angiotensin II concentration.
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U2 - 10.1016/S0022-3476(83)80491-0
DO - 10.1016/S0022-3476(83)80491-0
M3 - Article
C2 - 6355422
AN - SCOPUS:0021066019
SN - 0022-3476
VL - 103
SP - 806
EP - 810
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 5
ER -