Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats

Medicine & Life Sciences

• benzyl isothiocyanate 100%
• phenethyl isothiocyanate 94%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 90%
• Benzo(a)pyrene 72%
• DNA Adducts 24%
• 4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid 19%
• benzo(a)pyrene-DNA adduct 16%
• Hemoglobins 15%
• Diet 13%
• Lung 13%
• 4-hydroxy-1-(3-pyridyl)-1-butanone 10%
• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol 8%
• Carcinogenesis 7%
• Glucuronides 5%
• Liver 5%
• Drinking Water 4%
• Rodentia 4%