Effects of intracerebroventricular ethanol on ingestive behavior and induction of c-Fos immunoreactivity in selected brain regions

Daune L. Crankshaw, Jacquie E. Briggs, Pawel K. Olszewski, Qiuying Shi, Martha K. Grace, Charles J. Billington, Allen S. Levine

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25 Scopus citations

Abstract

The early changes in the central nervous system (CNS) following drinking of ethanol (ETOH) are poorly understood. It is known that chronic intracerebroventricular (ICV) administration of ethanol to rats induces preference for imbibed alcohol solutions. These results suggest that ICV ethanol could alter taste preference. In the present study, we tested whether ETOH{ICV} could induce a conditioned taste preference (CTP) or aversion (CTA) and alter c-Fos immunoreactivity (c-Fos-IR) in brain regions associated with feeding, aversion, and/or reward. Acute ETOH{ICV}, as tested in the ETOH-naïve rat, did not induce CTA nor affect the amount of water imbibed by treated rats. The effects of ETOH{ICV} on intake and preference were determined using a novel palatable (i.e. sweet) noncaloric 0.1% saccharin solution. A single dose of ETOH{ICV} in the ETOH-naïve animal induced a CTP for saccharin. ETOH{ICV} significantly increased c-Fos-IR in a number of brain sites associated with feeding and reward including the bed nucleus of the stria terminalis, lateral dorsal area (BSTLD); nucleus accumbens, shell area (AcbSh); hypothalamic paraventricular nucleus (PVN); and lateral septum, ventral area (LSV). Thus, ETOH induced a CTP, not CTA, via central mechanisms; it increased c-Fos-IR in specific sites associated with feeding and reward.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalPhysiology and Behavior
Volume79
Issue number1
DOIs
StatePublished - Jun 2003

Bibliographical note

Funding Information:
This work was supported by the National Institute on Alcohol Abuse and Alcoholism, the Department of Veterans Affairs, and the National Institute of Drug Abuse.

Keywords

  • Brain
  • Conditioned taste preference (CTP)
  • Ethanol (ETOH)
  • Immediate early gene c-Fos immunoreactivity (c-Fos-IR)
  • Intracerebroventricular (ICV)
  • Rats

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