Effects of urethane and ketamine on substance P- and excitatory amino acid-induced behavior in mice

Nelson L. Daló, Alice A. Larson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Urethane and ketamine were tested for their ability to alter the caudally directed binding and scratching response elicited by the intrathecal (i.t.) injection of excitatory amino acids (EAAs) or substance P (SP). EAAs, such as N-methyl-D-aspartate (NMDA), kainate acid and quisqualic acid, but not SP, were inhibited by subanesthetic doses of urethane. In contrast, SP was more sensitive than NMDA to the inhibitory effect of (+)-ketamine. (-)-Ketamine produced much less inhibition of the SP-induced behaviors than the (+)isomer. These results have important implications regarding the use of urethane and ketamine as anesthetics for studies in which these excitatory compounds are potential mediators.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalEuropean Journal of Pharmacology
Volume184
Issue number1
DOIs
StatePublished - Aug 2 1990

Keywords

  • Excitatory amino acids
  • Ketamine
  • Substance P
  • Urethane

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