TY - JOUR
T1 - Efficacy of convalescent plasma therapy for COVID-19
T2 - A systematic review and meta-analysis
AU - Vegivinti, Charan T.R.
AU - Pederson, John M.
AU - Saravu, Kavitha
AU - Gupta, Nitin
AU - Evanson, Kirk W.
AU - Kamrowski, Shelby
AU - Schmidt, Megan
AU - Barrett, Averi
AU - Trent, Hannah
AU - Dibas, Mahmoud
AU - Reierson, Natalie L.
AU - Mikoff, Nick
AU - Pisipati, Sailaja
AU - Joseph, Betsy A.
AU - Selvan, Pragadeesh T.
AU - Dmytriw, Adam A.
AU - Pulakurthi, Yashwitha S.
AU - Keesari, Praneeth R.
AU - Sriram, Varsha
AU - Chittajallu, Spandana
AU - Brinjikji, Waleed
AU - Katamreddy, Rewanth R.
AU - Chibbar, Richa
AU - Davis, Amber R.
AU - Malpe, Manashree
AU - Mishra, Hemant K.
AU - Kallmes, Kevin M.
AU - Hassan, Ameer E.
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2021/6
Y1 - 2021/6
N2 - The purpose of this systematic review and meta-analysis was to examine clinical outcomes associated with convalescent plasma therapy in COVID-19 patients. We performed a literature search on PubMed, medRxiv, Web of Science, and Scopus to identify studies published up to December 10th, 2020 that examined the efficacy of convalescent plasma treatment for COVID-19. The primary endpoints were mortality, clinical improvement, and hospital length of stay. We screened 859 studies that met the search criteria, performed full-text reviews of 56 articles, and identified 15 articles that fulfilled inclusion criteria for meta-analysis. The odds of mortality were significantly lower in the convalescent plasma group compared to the control group (OR = 0.59 [95% CI = 0.44; 0.78], P <.001), although results from two key randomized controlled trials did not support the mortality benefit. The odds of clinical improvement were significantly higher in the convalescent plasma group compared to the control group (OR = 2.02 [95% CI = 1.54; 2.65], P <.001). There was no difference in hospital length of stay between the convalescent plasma group and the control group (MD = −0.49 days [95% CI = −3.11; 2.12], P =.713). In all, these data indicate that a mortality benefit with convalescent plasma is unclear, although there remain benefits with convalescent plasma therapy for COVID-19.
AB - The purpose of this systematic review and meta-analysis was to examine clinical outcomes associated with convalescent plasma therapy in COVID-19 patients. We performed a literature search on PubMed, medRxiv, Web of Science, and Scopus to identify studies published up to December 10th, 2020 that examined the efficacy of convalescent plasma treatment for COVID-19. The primary endpoints were mortality, clinical improvement, and hospital length of stay. We screened 859 studies that met the search criteria, performed full-text reviews of 56 articles, and identified 15 articles that fulfilled inclusion criteria for meta-analysis. The odds of mortality were significantly lower in the convalescent plasma group compared to the control group (OR = 0.59 [95% CI = 0.44; 0.78], P <.001), although results from two key randomized controlled trials did not support the mortality benefit. The odds of clinical improvement were significantly higher in the convalescent plasma group compared to the control group (OR = 2.02 [95% CI = 1.54; 2.65], P <.001). There was no difference in hospital length of stay between the convalescent plasma group and the control group (MD = −0.49 days [95% CI = −3.11; 2.12], P =.713). In all, these data indicate that a mortality benefit with convalescent plasma is unclear, although there remain benefits with convalescent plasma therapy for COVID-19.
KW - COVID-19
KW - convalescent plasma
KW - coronavirus
KW - meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85100518612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100518612&partnerID=8YFLogxK
U2 - 10.1002/jca.21881
DO - 10.1002/jca.21881
M3 - Review article
C2 - 33544910
AN - SCOPUS:85100518612
SN - 0733-2459
VL - 36
SP - 470
EP - 482
JO - Journal of clinical apheresis
JF - Journal of clinical apheresis
IS - 3
ER -
