Abstract
Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil-emulsion adjuvanted vaccines and these differences were significant (p < 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.
Original language | English (US) |
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Pages (from-to) | 623-626 |
Number of pages | 4 |
Journal | Vaccine |
Volume | 10 |
Issue number | 9 |
DOIs | |
State | Published - 1992 |
Keywords
- Influenza
- liposomal avridine
- serological response
- surface charges
- turkeys
- vaccine