TY - JOUR
T1 - Epigenetic approaches in the treatment of myelodysplastic syndromes
T2 - Clinical utility of azacitidine
AU - Mccormack, Steven E.
AU - Warlick, Erica D
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Myelodysplastic syndromes (MDS) are a varied group of diseases leading to significant morbidity and mortality. Therapy of MDS has been difficult, with supportive cares used to ameliorate symptoms, and hematopoietic stem cell transplantation the only curative option. Agents, such as the cytidine analog azacitidine, exert an effect on DNA methyltransferase leading to a reduction in DNA methylation, a process thought to be key to the pathogenesis of MDS. Recently, azacitidine has been shown to prolong survival and improve quality of life in patients with MDS, while maintaining a favorable adverse effect profile. This review highlights the scientific rationale for the use of azacitidine in addition to its application in current clinical practice for patients with MDS.
AB - Myelodysplastic syndromes (MDS) are a varied group of diseases leading to significant morbidity and mortality. Therapy of MDS has been difficult, with supportive cares used to ameliorate symptoms, and hematopoietic stem cell transplantation the only curative option. Agents, such as the cytidine analog azacitidine, exert an effect on DNA methyltransferase leading to a reduction in DNA methylation, a process thought to be key to the pathogenesis of MDS. Recently, azacitidine has been shown to prolong survival and improve quality of life in patients with MDS, while maintaining a favorable adverse effect profile. This review highlights the scientific rationale for the use of azacitidine in addition to its application in current clinical practice for patients with MDS.
KW - Azacitidine
KW - Epigenetics
KW - Hypomethylation
KW - Myelodysplastic syndromes
UR - http://www.scopus.com/inward/record.url?scp=78649445235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649445235&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:78649445235
SN - 1178-6930
VL - 3
SP - 157
EP - 165
JO - OncoTargets and Therapy
JF - OncoTargets and Therapy
ER -