Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction

Ching Kim Tye, Changquan Sun, Gregory E. Amidon

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

It is well known that compression speed can have significant effects on the compaction properties of pharmaceutical powders. This is a challenge during scale up and technology transfer when tableting speeds are significantly increased. This study examined the effects of tableting speed on the compressibility (solid fraction vs. compaction pressure), tabletability (tensile strength vs. compaction pressure), and compactibility (tensile strength vs. solid fraction) of four common direct compression excipients and a placebo formulation. The tabletability and compressibility of some of these materials were observed to be speed dependent whereas the compactibility of all materials tested was essentially independent of tableting speed. It is therefore proposed that the compactibility profile (tensile strength vs. solid fraction) is a predictor that is independent of tableting speed and can be used to predict tablet strength during formulation development and scale up.

Original languageEnglish (US)
Pages (from-to)465-472
Number of pages8
JournalJournal of Pharmaceutical Sciences
Volume94
Issue number3
DOIs
StatePublished - Mar 2005

Keywords

  • Compactibility
  • Compaction
  • Compressibility
  • Compression
  • Excipients
  • Mechanical properties
  • Solid fraction
  • Speed
  • Tabletability
  • Tableting

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