Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway

Stephen Cose, Clair Brammer, Kamal M. Khanna, David Masopust, Leo Lefrançois

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Only activated and effector memory T cells are thought to access non-lymphoid tissues. In contrast, naive T cells are thought to circulate only between the blood, lymph and secondary lymphoid organs. We examined the phenotype of endogenous T cells in various non-lymphoid organs and showed that a subset of cells exhibited an apparently naive phenotype and were functionally inactive. FTY720 treatment selectively depleted this population from the non-lymphoid tissues. In addition, RAG-deficient TCR transgenic CD4 and CD8 T cells were present in non-lymphoid tissues in bone marrow chimeric mice and in situ imaging analysis revealed their location in the parenchymal tissues. Moreover, migration of TCR transgenic T cells to non-lymphoid tissues after adoptive transfer was pertussis-toxin resistant. Overall, the results suggest that naive T cells may circulate through non-lymphoid tissues as part of their normal migratory pathway.

Original languageEnglish (US)
Pages (from-to)1423-1433
Number of pages11
JournalEuropean Journal of Immunology
Volume36
Issue number6
DOIs
StatePublished - Jun 2006

Keywords

  • Cell migration
  • Cell trafficking
  • Naive cells

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