Evolving applications, technological challenges and future opportunities in neuromodulation: Proceedings of the fifth annual deep brain stimulation think tank

Adolfo Ramirez-Zamora, James J. Giordano, Aysegul Gunduz, Peter Brown, Justin C. Sanchez, Kelly D. Foote, Leonardo Almeida, Philip A. Starr, Helen M. Bronte-Stewart, Wei Hu, Cameron McIntyre, Wayne Goodman, Doe Kumsa, Warren M. Grill, Harrison C. Walker, Matthew D. Johnson, Jerrold L. Vitek, David Greene, Daniel S. Rizzuto, Dong SongTheodore W. Berger, Robert E. Hampson, Sam A. Deadwyler, Leigh R. Hochberg, Nicholas D. Schiff, Paul Stypulkowski, Greg Worrell, Vineet Tiruvadi, Helen S. Mayberg, Joohi Jimenez-Shahed, Pranav Nanda, Sameer A. Sheth, Robert E. Gross, Scott F. Lempka, Luming Li, Wissam Deeb, Michael S. Okun

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The annual Deep Brain Stimulation (DBS) Think Tank provides a focal opportunity for a multidisciplinary ensemble of experts in the field of neuromodulation to discuss advancements and forthcoming opportunities and challenges in the field. The proceedings of the fifth Think Tank summarize progress in neuromodulation neurotechnology and techniques for the treatment of a range of neuropsychiatric conditions including Parkinson's disease, dystonia, essential tremor, Tourette syndrome, obsessive compulsive disorder, epilepsy and cognitive, and motor disorders. Each section of this overview of the meeting provides insight to the critical elements of discussion, current challenges, and identified future directions of scientific and technological development and application. The report addresses key issues in developing, and emphasizes major innovations that have occurred during the past year. Specifically, this year's meeting focused on technical developments in DBS, design considerations for DBS electrodes, improved sensors, neuronal signal processing, advancements in development and uses of responsive DBS (closed-loop systems), updates on National Institutes of Health and DARPA DBS programs of the BRAIN initiative, and neuroethical and policy issues arising in and from DBS research and applications in practice.

Original languageEnglish (US)
Article number734
JournalFrontiers in Neuroscience
Issue numberJAN
StatePublished - Jan 24 2018

Bibliographical note

Funding Information:
SFL would like to thank Erika Woodrum (Louis Stokes Cleveland Veterans Affairs Medical Center) and Nicholas Maling, Ph.D. (Case Western Reserve University) for assistance generating Figure 7. JG is supported in part by funding from the European Union's Horizon 2020 Research and Innovation Program under grant agreement 720270: HBP SGA1, by the AEHS Foundation, and by federal funds UL1TR001409 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through the Clinical and Translational Science Awards Program (CTSA), a trademark of the Department of Health and Human Services, part of the Roadmap Initiative, "Re-Engineering the Clinical Research Enterprise." DS, TB, RH, and SD: this work was supported by DARPA RAM program (N66001-14-2-4032, N66001-14-C-4016). The views, opinions and/or findings expressed are those of the author and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. SS would like to acknowledge the Sackler and Gerstner Foundation for their support. JJ-S would like to thank the Michael J Fox Foundation for Parkinson's Research for providing a project planning grant for the development of RAD-PD design and infrastructure. Furthermore, RAD-PD is an approved study through the Parkinson Study Group and includes participation of Patient Advocates from the Parkinson Disease Foundation. JJ-S also would like to acknowledge the following collaborators and co-investigators: Nuri F. Ince, Ph.D.; Ilknur Telkes, Ph.D.; Ashwin Viswanathan, MD. LL would like to acknowledge grant support NSFC No. 81527901, No. 61601258, and 2016YFC0105502 2016YFC0105900. HW is supported by NIH grant UH3NS100553


  • Deep brain stimulation
  • Epilepsy
  • Memory
  • Neuromodulation
  • Obsessive compulsive disorder
  • Parkinson's disease
  • Tourette syndrome
  • Tremor

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