TY - JOUR
T1 - Expansion of cd16-negative natural killer cells in the peripheral blood of patients with metastatic melanoma
AU - Markovic, Svetomir N.
AU - Holtan, Shernan G.
AU - Creedon, Douglas J.
AU - Thompson, Michael A.
AU - Nevala, Wendy K.
PY - 2011
Y1 - 2011
N2 - Altered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated with altered NK homeostasis is normal pregnancy, where robust infiltration with CD16 CD9+ NK cells can be identified in decidual tissues, along with a concomitant expansion of CD16 NK cells in the maternal peripheral blood. In metastatic melanoma, we identified a similar expansion of peripheral blood CD16 NK cells (median 7.4 in 41 patients with melanoma compared with 3.0 in 29 controls, P<.001). A subset of NK cells in melanoma patients also expresses CD9, which is characteristically expressed only on NK cells within the female reproductive tract. Expansion of CD16 NK cells was associated with elevated plasma transforming growth factor-beta (TGF- levels (median 20ng/ml, Spearman's =0.81,P=.015)). These findings suggest the possibility of exploring anti-TGF- therapy to restore NK function in melanoma.
AB - Altered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated with altered NK homeostasis is normal pregnancy, where robust infiltration with CD16 CD9+ NK cells can be identified in decidual tissues, along with a concomitant expansion of CD16 NK cells in the maternal peripheral blood. In metastatic melanoma, we identified a similar expansion of peripheral blood CD16 NK cells (median 7.4 in 41 patients with melanoma compared with 3.0 in 29 controls, P<.001). A subset of NK cells in melanoma patients also expresses CD9, which is characteristically expressed only on NK cells within the female reproductive tract. Expansion of CD16 NK cells was associated with elevated plasma transforming growth factor-beta (TGF- levels (median 20ng/ml, Spearman's =0.81,P=.015)). These findings suggest the possibility of exploring anti-TGF- therapy to restore NK function in melanoma.
UR - http://www.scopus.com/inward/record.url?scp=79955112454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955112454&partnerID=8YFLogxK
U2 - 10.1155/2011/316314
DO - 10.1155/2011/316314
M3 - Article
C2 - 21403861
AN - SCOPUS:79955112454
SN - 1740-2522
VL - 2011
JO - Clinical and Developmental Immunology
JF - Clinical and Developmental Immunology
M1 - 316314
ER -
