Exploring routes to stabilize a cationic pyridoxamine in an artificial transaminase: Site-directed mutagenesis versus synthetic cofactors

Engineering & Materials Science

• Carrier Proteins 94%
• Mutagenesis 94%
• Fatty acids 72%
• Scaffolds 28%
• Enantioselectivity 23%
• Pyridine 19%
• Methylation 19%
• Molecular modeling 17%
• Enzymes 13%
• Normal distribution 13%
• Nitrogen 10%
• Proteins 10%
• Derivatives 9%

Chemical Compounds

• Pyridoxamine 84%
• Site-Directed Mutagenesis 61%
• Cofactor 54%
• Fatty Acid 47%
• Transamination 30%
• Protein 19%
• Turnover Number 13%
• Cyclic Structure 10%
• Molecular Modeling 10%
• Enantioselectivity 10%
• Flexibility 9%
• Pyridine 8%
• Nitrogen 7%
• pH Value 4%
• Acid 4%

Medicine & Life Sciences

• Pyridoxamine 100%
• Fatty Acid-Binding Proteins 77%
• Site-Directed Mutagenesis 63%
• Transaminases 61%
• pyridine 15%
• Nitrogen 11%
• Methylation 10%
• Amino Acids 8%
• Enzymes 6%
• Proteins 4%