Abstract
The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kidney and Wilms' tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms' tumor, a similar relationship was found. But in a monomorphous Wilms', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.
Original language | English (US) |
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Pages (from-to) | 522-526 |
Number of pages | 5 |
Journal | Laboratory Investigation |
Volume | 61 |
Issue number | 5 |
State | Published - 1989 |
Keywords
- Epithelial differentiation
- Nephrogenesis