Molecular analysis of 63 Escherichia coli urine isolates showed that pyelonephritis (n = 23) and prostatitis (n = 17) isolates exhibited more virulence factors (VFs) among the 35 sought than did cystitis isolates (n = 23). Several nontraditional VFs-including bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel siderophore receptors), cvaC (colicin [microcin] V), traT (serum-resistance associated), ibeA (invasion of brain endothelium), ompT (outer membrane protease T), and malX (pathogenicity island marker)-either differentiated significantly between syndromes (despite small numbers of isolates and possible multiple-comparison artifacts) or were broadly prevalent. Thus, interventions that target conserved uro-VFs may be possible, despite the likely existence of syndrome-specific pathogenetic mechanisms and/or host defense systems.
Bibliographical noteFunding Information:
Financial support: Office of Research and Development, Medical Research Service, Department of Veterans Affairs, and National Research Initiative Competitive Grants Program, US Department of Agriculture (grant 00-35212-9408 to J.R.J.); Ministry of Health, Spain (grant FIS 02/0327 to J.V.); Departament d’Universitats, Recerca I Societat de la Informació de la Generalitat de Catalunya, Spain (grant 2002 SGR00121 to J.V.). a Current affiliation: Aerotek Scientific, Arden Hills, Minnesota.