The phenomenon of enthalpy-entropy compensation in gas chromatography is examined. Using 53 probe solutes that span a wide range in size (dispersive interaction), dipolarity, hydrogen-bond-donor and hydrogen-bond-acceptor strength, enthalpy-entropy compensation is not observed, while for probe solutes within a homologous series enthalpy-entropy compensation is observed as predicted by the linear salvation energy relationship methodology.
Bibliographical noteFunding Information:
This work was supportedi n part by grants to the University of Minnesota from the National ScienceF oundation and the Petroleum Research Foundation.
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