TY - JOUR
T1 - Fast in vivo high-resolution diffusion MRI of the human cervical spinal cord microstructure
AU - Labounek, René
AU - Valošek, Jan
AU - Zimolka, Jakub
AU - Piskořová, Zuzana
AU - Horák, Tomáš
AU - Svátková, Alena
AU - Bednařík, Petr
AU - Hok, Pavel
AU - Vojtíšek, Lubomír
AU - Hluštík, Petr
AU - Bednařík, Josef
AU - Lenglet, Christophe
N1 - Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2019.
PY - 2019
Y1 - 2019
N2 - Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size ~1 × 1 × 5 mm3 being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 × 0.67 × 3 mm3 (after interpolation in Fourier space) covering the cervical segments C4–C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 × 0.35 × 2.5 mm3. Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.
AB - Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size ~1 × 1 × 5 mm3 being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 × 0.67 × 3 mm3 (after interpolation in Fourier space) covering the cervical segments C4–C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 × 0.35 × 2.5 mm3. Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.
KW - Cervical spinal cord
KW - Diffusion MRI
KW - HARDI
KW - High-resolution imaging
UR - http://www.scopus.com/inward/record.url?scp=85048257669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048257669&partnerID=8YFLogxK
U2 - 10.1007/978-981-10-9035-6_1
DO - 10.1007/978-981-10-9035-6_1
M3 - Conference article
AN - SCOPUS:85048257669
SN - 1680-0737
VL - 68
SP - 3
EP - 7
JO - IFMBE Proceedings
JF - IFMBE Proceedings
IS - 1
T2 - World Congress on Medical Physics and Biomedical Engineering, WC 2018
Y2 - 3 June 2018 through 8 June 2018
ER -