Fatal Complement-Induced Leukostasis After Diatrizoate Injection: Principles of Clinicopathologic Diagnosis

Henry Schneiderman, Dale E. Hammerschmidt, Anne Ritke McCall, Harry S. Jacob

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A case of fatal radiographic contrast medium (RCM)-induced pulmonary granulocyte aggregation (leukostasis) showed massive elevation of the postmortem histamine level. Suspicion of this phenomenon in diverse clinical settings permits clinical and pathological documentation via increased plasma levels of C3a and other means. The existence of effective prophylaxis stimulates a search for predictive tests.

Original languageEnglish (US)
Pages (from-to)2340-2342
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume250
Issue number17
DOIs
StatePublished - Nov 4 1983

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