Feeding response to central orexins

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Abstract

Orexin A and orexin B were microinjected into the perifornical hypothalamus (PFH), lateral hypothalamus (LH), hypothalamic paraventricular nucleus (PVN), and ventral tegmental area (VTA) of male Sprague-Dawley rats. Orexin B (15 nmol) was also injected into the lateral cerebral ventricle (i.c,v.). Orexin A (≥ 500 pmol) stimulated feeding in the PFH and LH, but not in the VTA or PVN. Orexin B stimulated feeding only when injected i.c.v.

Original languageEnglish (US)
Pages (from-to)535-538
Number of pages4
JournalBrain Research
Volume821
Issue number2
DOIs
StatePublished - Mar 13 1999

Bibliographical note

Funding Information:
This work was supported by funds from the Minnesota Obesity Center (P30 DK-50456).

Keywords

  • Feeding behavior
  • Hypocretin
  • Hypothalamic area, lateral
  • Hypothalamic area, perifornical
  • Hypothalamus
  • Orexin

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