Feeding response to central orexins

Donald C. Sweet; Allen S. Levine; Charles J. Billington; Catherine M. Kotz

doi:10.1016/S0006-8993(99)01136-1

Feeding response to central orexins

Donald C. Sweet, Allen S. Levine, Charles J. Billington, Catherine M. Kotz

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Abstract

Orexin A and orexin B were microinjected into the perifornical hypothalamus (PFH), lateral hypothalamus (LH), hypothalamic paraventricular nucleus (PVN), and ventral tegmental area (VTA) of male Sprague-Dawley rats. Orexin B (15 nmol) was also injected into the lateral cerebral ventricle (i.c,v.). Orexin A (≥ 500 pmol) stimulated feeding in the PFH and LH, but not in the VTA or PVN. Orexin B stimulated feeding only when injected i.c.v.

Original language	English (US)
Pages (from-to)	535-538
Number of pages	4
Journal	Brain Research
Volume	821
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)01136-1
State	Published - Mar 13 1999

Bibliographical note

Funding Information:
This work was supported by funds from the Minnesota Obesity Center (P30 DK-50456).

Keywords

Feeding behavior
Hypocretin
Hypothalamic area, lateral
Hypothalamic area, perifornical
Hypothalamus
Orexin

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title = "Feeding response to central orexins",

abstract = "Orexin A and orexin B were microinjected into the perifornical hypothalamus (PFH), lateral hypothalamus (LH), hypothalamic paraventricular nucleus (PVN), and ventral tegmental area (VTA) of male Sprague-Dawley rats. Orexin B (15 nmol) was also injected into the lateral cerebral ventricle (i.c,v.). Orexin A (≥ 500 pmol) stimulated feeding in the PFH and LH, but not in the VTA or PVN. Orexin B stimulated feeding only when injected i.c.v.",

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AU - Sweet, Donald C.

AU - Levine, Allen S.

AU - Billington, Charles J.

AU - Kotz, Catherine M.

N1 - Funding Information: This work was supported by funds from the Minnesota Obesity Center (P30 DK-50456).

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AB - Orexin A and orexin B were microinjected into the perifornical hypothalamus (PFH), lateral hypothalamus (LH), hypothalamic paraventricular nucleus (PVN), and ventral tegmental area (VTA) of male Sprague-Dawley rats. Orexin B (15 nmol) was also injected into the lateral cerebral ventricle (i.c,v.). Orexin A (≥ 500 pmol) stimulated feeding in the PFH and LH, but not in the VTA or PVN. Orexin B stimulated feeding only when injected i.c.v.

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KW - Hypocretin

KW - Hypothalamic area, lateral

KW - Hypothalamic area, perifornical

KW - Hypothalamus

KW - Orexin

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Feeding response to central orexins

Abstract

Bibliographical note

Keywords

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