Fetuin-A is not associated with mortality in chronic kidney disease

J. H. Ix, M. G. Shlipak, M. J. Sarnak, G. J. Beck, T. Greene, X. Wang, J. W. Kusek, Allan J Collins, A. S. Levey, V. Menon

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Fetuin-A is a serum protein that inhibits vascular calcification such that lower levels are associated with a higher prevalence of vascular calcification and mortality risk among end-stage renal disease populations. We analyzed data of 822 persons in the Modification of Diet in Renal Disease study, a randomized, controlled trial of persons with predominantly non-diabetic stage 3-4 chronic kidney disease (CKD). Serum fetuin-A levels were measured in baseline serum. Survival status and cause of death were determined by the National Death Index. Cox proportional hazard models evaluated the association of fetuin-A levels with all-cause and cardiovascular mortality. Glomerular filtration ranged from 13 to 55 ml per min per 1.73 m2. During a median follow-up of 9.5 years, 25% of persons died from any cause and 12% died from a cardiovascular cause. Compared to the lowest tertile, no association was found between the highest fetuin-A tertile and all-cause or cardiovascular mortality. Similarly, no association was found between fetuin-A as a continuous variable and all-cause or cardiovascular mortality. Our study shows that serum fetuin-A levels are not related to all-cause or cardiovascular mortality among persons with predominantly non-diabetic stage 3 or 4 CKD.

Original languageEnglish (US)
Pages (from-to)1394-1399
Number of pages6
JournalKidney international
Volume72
Issue number11
DOIs
StatePublished - Dec 2007

Keywords

  • Calcium
  • Cardiovascular disease
  • Chronic kidney disease
  • Mortality

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