Fibronectin in Foreign Body-Induced Sarcomas and Preneoplastic Cells

Gwen C. Macdonald; Leo T Furcht; K. Gerhard Brand

doi:10.3181/00379727-172-41532

Fibronectin in Foreign Body-Induced Sarcomas and Preneoplastic Cells

Gwen C. Macdonald, Leo T Furcht, K. Gerhard Brand

Laboratory Medicine and Pathology

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Abstract

Foreign body (FB)-induced murine sarcoma cells and advanced preneoplastic cells as well as normal fibroblasts produce fibronectin (FN) in primary culture; cells at early preneoplasia do not. Hence, the neoplastic properties of FB-induced sarcomas do not depend on absence of FN. Temporary FN repression during early preneoplasia is associated with certain phenotypic cell characteristics.

Original language	English (US)
Pages (from-to)	89-92
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	172
Issue number	1
DOIs	https://doi.org/10.3181/00379727-172-41532
State	Published - Jan 1983

Bibliographical note

Funding Information:
This investigation was supported by USPHS Grants CA 10712, CA 21463, CA 29995, and ES 02101 from the National Cancer Institute and the National Institute of Environmental Health Sciences, and from the Leukemia Task Force.

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title = "Fibronectin in Foreign Body-Induced Sarcomas and Preneoplastic Cells",

abstract = "Foreign body (FB)-induced murine sarcoma cells and advanced preneoplastic cells as well as normal fibroblasts produce fibronectin (FN) in primary culture; cells at early preneoplasia do not. Hence, the neoplastic properties of FB-induced sarcomas do not depend on absence of FN. Temporary FN repression during early preneoplasia is associated with certain phenotypic cell characteristics.",

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AU - Brand, K. Gerhard

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N2 - Foreign body (FB)-induced murine sarcoma cells and advanced preneoplastic cells as well as normal fibroblasts produce fibronectin (FN) in primary culture; cells at early preneoplasia do not. Hence, the neoplastic properties of FB-induced sarcomas do not depend on absence of FN. Temporary FN repression during early preneoplasia is associated with certain phenotypic cell characteristics.

AB - Foreign body (FB)-induced murine sarcoma cells and advanced preneoplastic cells as well as normal fibroblasts produce fibronectin (FN) in primary culture; cells at early preneoplasia do not. Hence, the neoplastic properties of FB-induced sarcomas do not depend on absence of FN. Temporary FN repression during early preneoplasia is associated with certain phenotypic cell characteristics.

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Fibronectin in Foreign Body-Induced Sarcomas and Preneoplastic Cells

Abstract

Bibliographical note

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