Foreign body (FB)-induced murine sarcoma cells and advanced preneoplastic cells as well as normal fibroblasts produce fibronectin (FN) in primary culture; cells at early preneoplasia do not. Hence, the neoplastic properties of FB-induced sarcomas do not depend on absence of FN. Temporary FN repression during early preneoplasia is associated with certain phenotypic cell characteristics.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jan 1983|
Bibliographical noteFunding Information:
This investigation was supported by USPHS Grants CA 10712, CA 21463, CA 29995, and ES 02101 from the National Cancer Institute and the National Institute of Environmental Health Sciences, and from the Leukemia Task Force.