Abstract
Fine needle aspiration cytologic (FNAC) findings of the thyroid in Graves' disease, following carbimazole therapy are rarely documented.
We present a case of 35-year-old female patient who clinically presented with thyromegaly and features of hyperthyroidism. A routine FNAC led to a diagnostic dilemma, with cytologic features indicative of Hashimoto's thyroiditis/colloid goiter with follicular hyperplasia, and in places raising even, a suspicion of malignant transformation. On further clinical details, it was found that the patient had defaulted carbimazole therapy for Graves' disease. Correlating the clinical and cytomorphologic features, a diagnosis of “therapy induced (carbimazole) changes in Graves' disease” was offered.
Therapy induced changes in Graves' disease can cause serious diagnostic dilemma on FNAC. The present case stresses the importance of obtaining history of therapy, when interpreting thyroid aspirates in patients with hyperthyroidism, in order to avoid unnecessary diagnostic confusions.
We present a case of 35-year-old female patient who clinically presented with thyromegaly and features of hyperthyroidism. A routine FNAC led to a diagnostic dilemma, with cytologic features indicative of Hashimoto's thyroiditis/colloid goiter with follicular hyperplasia, and in places raising even, a suspicion of malignant transformation. On further clinical details, it was found that the patient had defaulted carbimazole therapy for Graves' disease. Correlating the clinical and cytomorphologic features, a diagnosis of “therapy induced (carbimazole) changes in Graves' disease” was offered.
Therapy induced changes in Graves' disease can cause serious diagnostic dilemma on FNAC. The present case stresses the importance of obtaining history of therapy, when interpreting thyroid aspirates in patients with hyperthyroidism, in order to avoid unnecessary diagnostic confusions.
| Original language | English (US) |
|---|---|
| Journal | Internet Journal of Endocrinology |
| Volume | 4 |
| Issue number | 2 |
| State | Published - 2008 |