First trimester phthalate exposure and infant birth weight in the infant development and environment study

Sheela Sathyanarayana, Emily Barrett, Ruby Nguyen, Bruce Redmon, Wren Haaland, Shanna H. Swan

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10 Scopus citations


Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010-2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females (N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants.

Original languageEnglish (US)
Article number945
JournalInternational journal of environmental research and public health
Issue number10
StatePublished - Oct 2016

Bibliographical note

Funding Information:
Funding for this study was supported by NIEHS R01 ES016863-02S4. The funding organization did not contribute to any aspect of design, data collection, or analysis within the study. We acknowledge the contributions of the entire TIDES Study Team: Coordinating Center: Fan Liu, Erica Scher; UCSF: Sarah Janssen, Marina Stasenko, Erin Ayash, Melissa Schirmer, Jason Farrell, Mari-Paule Thiet, Laurence Baskin; UMN: Chelsea Georgesen, Heather L. Gray, Brooke J. Rody, Carrie A. Terrell, Kapilmeet Kaur; URMC: Erin Brantley, Heather Fiore, Lynda Kochman, Lauren Parlett, Jessica Marino, Eva Pressman; UW: Kristy Ivicek, Bobbie Salveson, Garry Alcedo. The team was responsible for the conduct of the study, data collection, and management.

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.


  • Birth weight
  • Fetal growth
  • First trimester
  • Phthalate
  • Preterm

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