The frequency, differential diagnosis, and implications of depression occurring in the course of schizophrenia are considered in light of recently reported findings from a follow-up and family study of 500 psychiatric outpatients (the St. Louis 500 Study). Problems in diagnosis are illustrated in an interview of a schizophrenic patient with a history of depression. Nearly 60% of the schizophrenics studied had suffered a depressive syndrome during the course of their schizophrenic illness, supporting the observations of others. The majority of patients with a history of depression who were otherwise diagnosable as schizophrenic had a course of illness consistent with schizophrenia during follow-up. The pattern of illness among first-degree relatives suggested that intercurrent depression did not represent a biologic unity with primary affective disorder. Intercurrent depression should not be overinterpreted in excluding a diagnosis of schizophrenia.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Clinical Psychiatry|
|Issue number||11 II|
|State||Published - Dec 1 1985|