Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospital

T. A. Larson, C. R. Garrett, D. N. Gerding

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The incidence of tobramycin-resistant, gentamicin-susceptible Serratia species at the Minneapolis Veterans Administration Medical Center decreased from an average 42.1 to 2.5% (P<0.001) during a 4.5-year period despite the predominant use of amikacin. These organisms were shown to express a 6'-N-acetyltransferase-modifying enzyme (EC 2.3.1.82). Resistance was not shown to be plasmid mediated.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume30
Issue number1
DOIs
StatePublished - 1986

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