FTD and ALS: Genetic ties that bind

Harry T. Orr

doi:10.1016/j.neuron.2011.10.001

FTD and ALS: Genetic ties that bind

Harry T. Orr

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

25 Scopus citations

Abstract

Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.

Original language	English (US)
Pages (from-to)	189-190
Number of pages	2
Journal	Neuron
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2011.10.001
State	Published - Oct 20 2011

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abstract = "Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.",

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AB - Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.

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FTD and ALS: Genetic ties that bind

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