FTD and ALS: Genetic ties that bind

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations

Abstract

Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis.

Original languageEnglish (US)
Pages (from-to)189-190
Number of pages2
JournalNeuron
Volume72
Issue number2
DOIs
StatePublished - Oct 20 2011

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