Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension

Medicine & Life Sciences

• 3-hydroxy-3-methylglutaryl-coenzyme A 100%
• Hydroxymethylglutaryl CoA Reductases 90%
• Essential Hypertension 80%
• Oxidoreductases 69%
• Hypotension 50%
• Hypertension 49%
• Genes 30%
• Luciferases 30%
• Single Nucleotide Polymorphism 27%
• Transcription Factors 24%
• Blood Pressure 20%
• Plasmids 17%
• Cholesterol 16%
• Gene Expression 13%
• Electrophoretic Mobility Shift Assay 11%
• Nuclear Proteins 11%
• Liver 11%
• Nicotine 10%
• Transfection 9%
• Kidney 5%

Agriculture & Biology

• hydroxymethylglutaryl-CoA reductases 99%
• hypertension 81%
• animal models 66%
• genetic polymorphism 56%
• promoter regions 54%
• hypotension 47%
• genes 26%
• luciferase 25%
• blood pressure 22%
• single nucleotide polymorphism 21%
• transcription factors 17%
• cholesterol 11%
• plasmids 11%
• gene expression 9%
• liver 8%
• nicotine 8%
• mice 8%
• nuclear proteins 8%
• essential genes 8%
• transfection 8%
• neurons 6%
• kidneys 5%
• loci 4%
• assays 4%

Chemical Compounds

• Blood Pressure 96%
• Nucleotide 12%
• Hypertensive 7%
• Nicotine 6%
• Antihypertensive 6%
• Kd 3%
• Plasma 3%
• Amount 2%
• Protein 2%