GABA binding in the brains of aggressive and non-aggressive female hamsters

M. Potegal; A. S. Perumal; A. I. Barkai; G. E. Cannova; A. D. Blau

doi:10.1016/0006-8993(82)91256-2

GABA binding in the brains of aggressive and non-aggressive female hamsters

M. Potegal, A. S. Perumal, A. I. Barkai, G. E. Cannova, A. D. Blau

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Ovariectomized female hamsters were selected for agrressiveness of non-aggressiveness toward a drug-treated target hamster. Animals in the aggressive group were found to have significantly higher levels of GABA binding in their brain 'midregions' (including limbic, striatal and diencephalic structures). There were no between-group GABA binding differences in cortex or pons/medulla and no differences in dihydroalprenolol (DHA) binding in any of these three regions. The groups did not differ on a variety of other behavioral tests including measures of activity, emotionality, feeding, and hormonally primed sexual behavior. The differences in 'midregion' GABA binding therefore may relate to levels of aggressiveness specifically.

Original language	English (US)
Pages (from-to)	315-324
Number of pages	10
Journal	Brain Research
Volume	247
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)91256-2
State	Published - Sep 16 1982
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Dr. Ralph Noble for his advice on the design of the lordosis test and Mrs. Ludmila Skaredoff for her assistance at several other stages of this project. This work was supported in part by a grant from the Harry F. Guggenheim Foundation.

Keywords

GABA binding
dihydroprenolol binding
hamster
intraspecific aggression
receptors

Access

10.1016/0006-8993(82)91256-2

OpenUrl availability

Full text

Cite this

@article{238def59fc374a76ab6df71d8618e7cd,

title = "GABA binding in the brains of aggressive and non-aggressive female hamsters",

abstract = "Ovariectomized female hamsters were selected for agrressiveness of non-aggressiveness toward a drug-treated target hamster. Animals in the aggressive group were found to have significantly higher levels of GABA binding in their brain 'midregions' (including limbic, striatal and diencephalic structures). There were no between-group GABA binding differences in cortex or pons/medulla and no differences in dihydroalprenolol (DHA) binding in any of these three regions. The groups did not differ on a variety of other behavioral tests including measures of activity, emotionality, feeding, and hormonally primed sexual behavior. The differences in 'midregion' GABA binding therefore may relate to levels of aggressiveness specifically.",

keywords = "GABA binding, dihydroprenolol binding, hamster, intraspecific aggression, receptors",

author = "M. Potegal and Perumal, {A. S.} and Barkai, {A. I.} and Cannova, {G. E.} and Blau, {A. D.}",

note = "Funding Information: We would like to thank Dr. Ralph Noble for his advice on the design of the lordosis test and Mrs. Ludmila Skaredoff for her assistance at several other stages of this project. This work was supported in part by a grant from the Harry F. Guggenheim Foundation.",

year = "1982",

month = sep,

day = "16",

doi = "10.1016/0006-8993(82)91256-2",

language = "English (US)",

volume = "247",

pages = "315--324",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - GABA binding in the brains of aggressive and non-aggressive female hamsters

AU - Potegal, M.

AU - Perumal, A. S.

AU - Barkai, A. I.

AU - Cannova, G. E.

AU - Blau, A. D.

N1 - Funding Information: We would like to thank Dr. Ralph Noble for his advice on the design of the lordosis test and Mrs. Ludmila Skaredoff for her assistance at several other stages of this project. This work was supported in part by a grant from the Harry F. Guggenheim Foundation.

PY - 1982/9/16

Y1 - 1982/9/16

N2 - Ovariectomized female hamsters were selected for agrressiveness of non-aggressiveness toward a drug-treated target hamster. Animals in the aggressive group were found to have significantly higher levels of GABA binding in their brain 'midregions' (including limbic, striatal and diencephalic structures). There were no between-group GABA binding differences in cortex or pons/medulla and no differences in dihydroalprenolol (DHA) binding in any of these three regions. The groups did not differ on a variety of other behavioral tests including measures of activity, emotionality, feeding, and hormonally primed sexual behavior. The differences in 'midregion' GABA binding therefore may relate to levels of aggressiveness specifically.

AB - Ovariectomized female hamsters were selected for agrressiveness of non-aggressiveness toward a drug-treated target hamster. Animals in the aggressive group were found to have significantly higher levels of GABA binding in their brain 'midregions' (including limbic, striatal and diencephalic structures). There were no between-group GABA binding differences in cortex or pons/medulla and no differences in dihydroalprenolol (DHA) binding in any of these three regions. The groups did not differ on a variety of other behavioral tests including measures of activity, emotionality, feeding, and hormonally primed sexual behavior. The differences in 'midregion' GABA binding therefore may relate to levels of aggressiveness specifically.

KW - GABA binding

KW - dihydroprenolol binding

KW - hamster

KW - intraspecific aggression

KW - receptors

UR - http://www.scopus.com/inward/record.url?scp=0019935103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019935103&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(82)91256-2

DO - 10.1016/0006-8993(82)91256-2

M3 - Article

C2 - 6889905

AN - SCOPUS:0019935103

SN - 0006-8993

VL - 247

SP - 315

EP - 324

JO - Brain Research

JF - Brain Research

IS - 2

ER -

GABA binding in the brains of aggressive and non-aggressive female hamsters

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this