Gels without Vapor Pressure: Soft, Nonaqueous, and Solvent-Free Supramolecular Biomaterials for Prospective Parenteral Drug Delivery Applications

The engineering advantages of soft, nonaqueous, solvent-free supramolecular materials have resulted in their emerging transition and adoption from a predominantly food, cosmetics, and paint industry-driven technology to biocompatible matrices for parenteral drug delivery. Factors that have contributed to this trend are the drastic increase of hydrophobic and combination drugs in the pharmaceutical pipeline and the limitations of hydrated drug delivery materials with regard to poorly soluble drugs and biologics. This review highlights examples of nonaqueous, soft supramolecular materials, illustrates molecular engineering principles that may give rise to novel structures and unique properties, and explores emerging opportunities of application of these materials in parenteral drug delivery.