TY - JOUR
T1 - Gene polymorphisms of interleukin-4, interleukin-10 and transforming growth factor-beta in Graves' disease
AU - Khalilzadeh, Omid
AU - Anvari, Mehdi
AU - Momen-Heravi, Fatemeh
AU - Esteghamati, Alireza
AU - Rashidi, Armin
AU - Mahmoudi, Mahdi
AU - Nikbin, Behrouz
AU - Amirzargar, Aliakbar
N1 - Funding Information:
This study was supported by a grant from Tehran University of Medical Sciences (TUMS), Tehran, Iran
PY - 2010/6
Y1 - 2010/6
N2 - Among genetic factors that may contribute to the development and progression of Graves' disease (GD) and its complications are polymorphisms in the genes encoding cytokines. The association between GD and the following polymorphisms in anti-inflammatory cytokines was studied in 107 patients with GD and 140 healthy controls: IL-4 (-1098T/G, -590T/C, -33C/T), IL-10 (-1082A/G, -819C/T, -592C/A) and TGF-β (+869T/C, +915G/C). The following alleles and genotypes were significantly (P<0.01 after correction for multiple testing) more frequent among patients: the IL-4 -1098G allele and GG genotype (OR = 3.12 and 105.00, respectively), IL-4 -33T allele and TT genotype (OR = 2.52 and 118.83, respectively), IL-10 -1082G allele and GG genotype (OR = 2.16 and 6.40, respectively), IL-10 -819T allele, TC and TT genotype (OR = 2.60, 3.68 and 6.76, respectively), IL-10 -592A allele, AC and AA genotype (OR = 2.41, 2.89 and 5.68, respectively), TGF-β +869C allele and CC genotype (OR = 2.24 and 6.21, respectively), and TGF-β +915C allele, CG and CC genotype (OR = 7.81, 11.80 and 20.40, respectively). The only allele and genotype with a lower frequency in patients were IL-4 -590T allele and TC genotype (OR = 0.47 and 0.08, respectively; P<0.01). In conclusion, this study highlighted the importance of anti-inflammatory cytokine gene polymorphisms in susceptibility to GD.
AB - Among genetic factors that may contribute to the development and progression of Graves' disease (GD) and its complications are polymorphisms in the genes encoding cytokines. The association between GD and the following polymorphisms in anti-inflammatory cytokines was studied in 107 patients with GD and 140 healthy controls: IL-4 (-1098T/G, -590T/C, -33C/T), IL-10 (-1082A/G, -819C/T, -592C/A) and TGF-β (+869T/C, +915G/C). The following alleles and genotypes were significantly (P<0.01 after correction for multiple testing) more frequent among patients: the IL-4 -1098G allele and GG genotype (OR = 3.12 and 105.00, respectively), IL-4 -33T allele and TT genotype (OR = 2.52 and 118.83, respectively), IL-10 -1082G allele and GG genotype (OR = 2.16 and 6.40, respectively), IL-10 -819T allele, TC and TT genotype (OR = 2.60, 3.68 and 6.76, respectively), IL-10 -592A allele, AC and AA genotype (OR = 2.41, 2.89 and 5.68, respectively), TGF-β +869C allele and CC genotype (OR = 2.24 and 6.21, respectively), and TGF-β +915C allele, CG and CC genotype (OR = 7.81, 11.80 and 20.40, respectively). The only allele and genotype with a lower frequency in patients were IL-4 -590T allele and TC genotype (OR = 0.47 and 0.08, respectively; P<0.01). In conclusion, this study highlighted the importance of anti-inflammatory cytokine gene polymorphisms in susceptibility to GD.
KW - Cytokine
KW - Gene
KW - Graves' disease
KW - Interleukin
KW - Polymorphism
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U2 - 10.1007/s10238-009-0078-5
DO - 10.1007/s10238-009-0078-5
M3 - Article
C2 - 19882211
AN - SCOPUS:77954672431
SN - 1591-8890
VL - 10
SP - 123
EP - 128
JO - Clinical and Experimental Medicine
JF - Clinical and Experimental Medicine
IS - 2
ER -