Although bone is one of the few organs in the body that can heal spontaneously and restore function without scarring, it has been recognized since the time of Hippocrates that repair is not always satisfactory.Bone healing is inadequate when the loss of bone through, for example, tumor resection or traumatic injury, is extensive enough to produce a critical-sized defect.Healing may also be impaired in much smaller defects, and nonunion following fracture occurs in 5-10%of cases (1-3).
|Original language||English (US)|
|Title of host publication||Bone Regeneration and Repair|
|Subtitle of host publication||Biology and Clinical Applications|
|Number of pages||12|
|ISBN (Print)||0896038475, 9780896038479|
|State||Published - Dec 1 2005|