Abstract
(Figure Presented) Spatial control of bioactive ligands is achieved by integrating microfluidics and protein engineering. The proteins of interest are mixed in a gradient generator and immobilized on artificial polypeptide scaffolds through the strong association of heterodimeric ZE/ZR leucine zipper pairs. Protein densities and gradient shapes are easily controlled and varied in this method.
Original language | English (US) |
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Pages (from-to) | 2617-2619 |
Number of pages | 3 |
Journal | ChemBioChem |
Volume | 10 |
Issue number | 16 |
DOIs | |
State | Published - Nov 2 2009 |
Keywords
- Cell adhesion
- Coiled coils
- Microfluidics
- Proteins
- Surface functionalization