TY - JOUR
T1 - Genetic influences on growth traits of BMI
T2 - A longitudinal study of adult twins
AU - Hjelmborg, Jacob V B
AU - Fagnani, Corrado
AU - Silventoinen, Karri
AU - McGue, Matt
AU - Korkeila, Maarit
AU - Christensen, Kaare
AU - Rissanen, Aila
AU - Kaprio, Jaakko
PY - 2008/4
Y1 - 2008/4
N2 - Objective:To investigate the interplay between genetic factors influencing baseline level and changes in BMI in adulthood.Methods and Procedures:A longitudinal twin study of the cohort of Finnish twins (N = 10,556 twin individuals) aged 20-46 years at baseline was conducted and followed up 15 years. Data on weight and height were obtained from mailed surveys in 1975, 1981, and 1990.Results:Latent growth models revealed a substantial genetic influence on BMI level at baseline in males and females (heritability (h 2) 80% (95% confidence interval 0.79-0.80) for males and h 2 = 82% (0.81, 0.84) for females) and a moderate-to-high influence on rate of change in BMI (h2 = 58% (0.50, 0.69) for males and h 2 = 64% (0.58, 0.69) for females). Only very weak evidence for genetic pleiotropy was observed; the genetic correlation between baseline and rate of change in BMI was very modest (-0.070 (-0.13, -0.068) for males and 0.04 (0.00, 0.08) for females.Discussion:Our population-based results provide a basis for identifying genetic variants for change in BMI, in particular weight gain. Furthermore, they demonstrate for the first time that such genetic variants for change in BMI are likely to be different from those affecting level of BMI.
AB - Objective:To investigate the interplay between genetic factors influencing baseline level and changes in BMI in adulthood.Methods and Procedures:A longitudinal twin study of the cohort of Finnish twins (N = 10,556 twin individuals) aged 20-46 years at baseline was conducted and followed up 15 years. Data on weight and height were obtained from mailed surveys in 1975, 1981, and 1990.Results:Latent growth models revealed a substantial genetic influence on BMI level at baseline in males and females (heritability (h 2) 80% (95% confidence interval 0.79-0.80) for males and h 2 = 82% (0.81, 0.84) for females) and a moderate-to-high influence on rate of change in BMI (h2 = 58% (0.50, 0.69) for males and h 2 = 64% (0.58, 0.69) for females). Only very weak evidence for genetic pleiotropy was observed; the genetic correlation between baseline and rate of change in BMI was very modest (-0.070 (-0.13, -0.068) for males and 0.04 (0.00, 0.08) for females.Discussion:Our population-based results provide a basis for identifying genetic variants for change in BMI, in particular weight gain. Furthermore, they demonstrate for the first time that such genetic variants for change in BMI are likely to be different from those affecting level of BMI.
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U2 - 10.1038/oby.2007.135
DO - 10.1038/oby.2007.135
M3 - Article
C2 - 18239571
AN - SCOPUS:41549131814
SN - 1930-7381
VL - 16
SP - 847
EP - 852
JO - Obesity
JF - Obesity
IS - 4
ER -