Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

M. N. Blumenthal; D. B. Amos; H. Noreen; N. R. Mendell; E. J. Yunis

doi:10.1126/science.184.4143.1301

Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

M. N. Blumenthal, D. B. Amos, H. Noreen, N. R. Mendell, E. J. Yunis

Medicine - Pulmonary, Allergy, Critical

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Abstract

Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

Original language	English (US)
Pages (from-to)	1301-1303
Number of pages	3
Journal	Science
Volume	184
Issue number	4143
DOIs	https://doi.org/10.1126/science.184.4143.1301
State	Published - 1974

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abstract = "Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.",

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AU - Blumenthal, M. N.

AU - Amos, D. B.

AU - Noreen, H.

AU - Mendell, N. R.

AU - Yunis, E. J.

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AB - Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

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Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

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