Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension

Russell A. Wilke; Robert U. Simpson; Bickol N. Mukesh; Satya V. Bhupathi; Richard A. Dart; Nader R. Ghebranious; Catherine A. McCarty

doi:10.2217/pgs.09.101

Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension

Russell A. Wilke, Robert U. Simpson, Bickol N. Mukesh, Satya V. Bhupathi, Richard A. Dart, Nader R. Ghebranious, Catherine A. McCarty

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Abstract

Aims: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. Materials & methods: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender). Results: In the context of hypertension, a SNP in CYP27B1 was associated with congestive heart failure (odds ratio: 2.14 for subjects homozygous for the C allele; 95% CI: 1.05-4.39). Conclusion: Genetic variation in vitamin D biosynthesis is associated with increased risk of heart failure.

Original language	English (US)
Pages (from-to)	1789-1797
Number of pages	9
Journal	Pharmacogenomics
Volume	10
Issue number	11
DOIs	https://doi.org/10.2217/pgs.09.101
State	Published - 2009

Keywords

Congestive heart failure
Genetics
Hypertension
Vitamin D

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title = "Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension",

abstract = "Aims: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. Materials & methods: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender). Results: In the context of hypertension, a SNP in CYP27B1 was associated with congestive heart failure (odds ratio: 2.14 for subjects homozygous for the C allele; 95% CI: 1.05-4.39). Conclusion: Genetic variation in vitamin D biosynthesis is associated with increased risk of heart failure.",

keywords = "Congestive heart failure, Genetics, Hypertension, Vitamin D",

author = "Wilke, {Russell A.} and Simpson, {Robert U.} and Mukesh, {Bickol N.} and Bhupathi, {Satya V.} and Dart, {Richard A.} and Ghebranious, {Nader R.} and McCarty, {Catherine A.}",

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AU - Wilke, Russell A.

AU - Simpson, Robert U.

AU - Mukesh, Bickol N.

AU - Bhupathi, Satya V.

AU - Dart, Richard A.

AU - Ghebranious, Nader R.

AU - McCarty, Catherine A.

PY - 2009

Y1 - 2009

N2 - Aims: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. Materials & methods: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender). Results: In the context of hypertension, a SNP in CYP27B1 was associated with congestive heart failure (odds ratio: 2.14 for subjects homozygous for the C allele; 95% CI: 1.05-4.39). Conclusion: Genetic variation in vitamin D biosynthesis is associated with increased risk of heart failure.

AB - Aims: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. Materials & methods: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender). Results: In the context of hypertension, a SNP in CYP27B1 was associated with congestive heart failure (odds ratio: 2.14 for subjects homozygous for the C allele; 95% CI: 1.05-4.39). Conclusion: Genetic variation in vitamin D biosynthesis is associated with increased risk of heart failure.

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KW - Genetics

KW - Hypertension

KW - Vitamin D

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Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension

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