Abstract
Malignant hyperthermia susceptibility (MHS) and the associated condition malignant hyperthermia (MH) are rare but well-known disorders in the field of anesthesiology. MHS is usually determined by a history of a family member developing a positive episode during general anesthesia and then confirmed by an invasive caffeine halothane contracture test (CHCT). More recently, within the context of MH as a pharmacogenetic disorder, the question of whether or not MHS can be principally genetically determined is of high importance as knowledge of detailed pathogenesis may prevent against its largely invariable lethality if untreated. Thus, in this brief report, genetic terms, as well as updates in the genetics of MHS, will be reviewed in order to better understand both the condition and the current research.
Original language | English (US) |
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Pages (from-to) | 552-555 |
Number of pages | 4 |
Journal | Journal of Anaesthesiology Clinical Pharmacology |
Volume | 36 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2020 |
Bibliographical note
Publisher Copyright:© 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Keywords
- Genetic testing
- MH susceptibility
- malignant hyperthermia (MH)