Haloperidol Concentrations in Patients With Alzheimer's Dementia

Maurice W. Dysken; Sue B. Johnson; Lori Holden; Govind Vatassery; Julie Nygren; Mary Jelinski; Michael Kuskowski; Larry Schut; J. Riley McCarten; David Knopman; Gabe J. Maletta; Stacy Skare

doi:10.1097/00019442-199405000-00006

Haloperidol Concentrations in Patients With Alzheimer's Dementia

Maurice W. Dysken, Sue B. Johnson, Lori Holden, Govind Vatassery, Julie Nygren, Mary Jelinski, Michael Kuskowski, Larry Schut, J. Riley McCarten, David Knopman, Gabe J. Maletta, Stacy Skare

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Abstract

To investigate the relationship between clinical response and haloperidol blood concentrations in Alzheimer's dementia (AD) patients with behavior problems, 29 AD inpatients were assigned to a fixed oral dosage of haloperidol (0.5 mg, 1.0 mg, or 2.0 mg) every 12 hours for 3 weeks. BEHAVE-AD ratings and concentrations of plasma and RBC haloperidol and reduced haloperidol were obtained on Days 8, 15, and 22. Although no significant linear or curvilinear relationships were apparent between percent of change on BEHAVE-AD and plasma or RBC haloperidol concentrations, a good response (change ≥ 30%) was observed in 55% of the patients who entered the study.

Original language	English (US)
Pages (from-to)	124-133
Number of pages	10
Journal	American Journal of Geriatric Psychiatry
Volume	2
Issue number	2
DOIs	https://doi.org/10.1097/00019442-199405000-00006
State	Published - 1994
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a Merit Review Grant from Department of Veterans Affairs Medical Research.

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title = "Haloperidol Concentrations in Patients With Alzheimer's Dementia",

abstract = "To investigate the relationship between clinical response and haloperidol blood concentrations in Alzheimer's dementia (AD) patients with behavior problems, 29 AD inpatients were assigned to a fixed oral dosage of haloperidol (0.5 mg, 1.0 mg, or 2.0 mg) every 12 hours for 3 weeks. BEHAVE-AD ratings and concentrations of plasma and RBC haloperidol and reduced haloperidol were obtained on Days 8, 15, and 22. Although no significant linear or curvilinear relationships were apparent between percent of change on BEHAVE-AD and plasma or RBC haloperidol concentrations, a good response (change ≥ 30%) was observed in 55% of the patients who entered the study.",

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doi = "10.1097/00019442-199405000-00006",

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AU - Johnson, Sue B.

AU - Holden, Lori

AU - Vatassery, Govind

AU - Nygren, Julie

AU - Jelinski, Mary

AU - Kuskowski, Michael

AU - Schut, Larry

AU - McCarten, J. Riley

AU - Knopman, David

AU - Maletta, Gabe J.

AU - Skare, Stacy

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AB - To investigate the relationship between clinical response and haloperidol blood concentrations in Alzheimer's dementia (AD) patients with behavior problems, 29 AD inpatients were assigned to a fixed oral dosage of haloperidol (0.5 mg, 1.0 mg, or 2.0 mg) every 12 hours for 3 weeks. BEHAVE-AD ratings and concentrations of plasma and RBC haloperidol and reduced haloperidol were obtained on Days 8, 15, and 22. Although no significant linear or curvilinear relationships were apparent between percent of change on BEHAVE-AD and plasma or RBC haloperidol concentrations, a good response (change ≥ 30%) was observed in 55% of the patients who entered the study.

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Haloperidol Concentrations in Patients With Alzheimer's Dementia

Abstract

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