Heart rate and blood pressure: Any possible implications for management of hypertension

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Hypertension is a common clinical problem and a major risk factor for cardiovascular disease and stroke. Elevated heart rate is associated with elevated blood pressure, increased risk for hypertension, and, among hypertensives, increased risk for cardiovascular disease. Despite these important relationships, heart rate is generally not a major consideration in choosing antihypertensive medications. In part, this is due to a lack of evidence supporting heart rate lowering as a therapeutic strategy in hypertension. Additionally, while there is a positive correlation between heart rate and peripheral blood pressure, there is an inverse relationship between heart rate and central blood pressure. The use of antihypertensive medications, specifically medications that affect heart rate, may not reliably reduce central blood pressure to a similar extent as observed peripherally.We review the relationship between heart rate and peripheral and central blood pressure, with a focus on the implications for chronotropic therapy in hypertension.

Original languageEnglish (US)
Pages (from-to)478-484
Number of pages7
JournalCurrent Hypertension Reports
Volume14
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • Antihypertensive agents
  • Augmentation index
  • Beta-blockers
  • CKD
  • Cardiovascular disease
  • Central blood pressure
  • Chronic kidney disease
  • Heart rate
  • Hypertension
  • PWV
  • Peripheral blood pressure
  • Pulse wave velocities
  • Stroke

Fingerprint Dive into the research topics of 'Heart rate and blood pressure: Any possible implications for management of hypertension'. Together they form a unique fingerprint.

Cite this