Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies

Kanwaldeep Mallhi; Lawrence G. Lum; Kirk R. Schultz; Maxim Yankelevich

doi:10.1016/j.pcl.2014.10.001

Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies

Kanwaldeep Mallhi, Lawrence G. Lum, Kirk R. Schultz, Maxim Yankelevich

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.

Original language	English (US)
Pages (from-to)	257-273
Number of pages	17
Journal	Pediatric clinics of North America
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.pcl.2014.10.001
State	Published - Feb 1 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Adolescents
Cancer
Cellular therapy
Children
Hematopoietic cell transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.pcl.2014.10.001

OpenUrl availability

Full text

Cite this

@article{cd28cc78d942462a974d08ef9078e2af,

title = "Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies",

abstract = "Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.",

keywords = "Adolescents, Cancer, Cellular therapy, Children, Hematopoietic cell transplantation",

author = "Kanwaldeep Mallhi and Lum, {Lawrence G.} and Schultz, {Kirk R.} and Maxim Yankelevich",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.pcl.2014.10.001",

language = "English (US)",

volume = "62",

pages = "257--273",

journal = "Pediatric clinics of North America",

issn = "0031-3955",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies

AU - Mallhi, Kanwaldeep

AU - Lum, Lawrence G.

AU - Schultz, Kirk R.

AU - Yankelevich, Maxim

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.

AB - Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.

KW - Adolescents

KW - Cancer

KW - Cellular therapy

KW - Children

KW - Hematopoietic cell transplantation

UR - http://www.scopus.com/inward/record.url?scp=84915749962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84915749962&partnerID=8YFLogxK

U2 - 10.1016/j.pcl.2014.10.001

DO - 10.1016/j.pcl.2014.10.001

M3 - Review article

C2 - 25435122

AN - SCOPUS:84915749962

SN - 0031-3955

VL - 62

SP - 257

EP - 273

JO - Pediatric clinics of North America

JF - Pediatric clinics of North America

IS - 1

ER -

Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this