Hepatic mixed-function oxidase activity in rainbow trout exposed to several polycyclic aromatic compounds

Ellen Heath Gerhart, Robert M Carlson

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The effects of polycyclic aromatic hydrocarbons (PAHs) on microsomal liver enzymes were examined in rainbow trout. Various PAHs (naphthalene through benzo(a)pyrene [B(aP]) were injected ip to screen for mixed-function oxidase (MFO) activity. Chrysene, B(a)P, and Aroclor 1254 caused MFO induction. When fish were also exposed to solubilized pyrene, fluoranthene, and B(a)P in water, bioaccumulation of B(a)P resulted in MFO induction, whereas bioaccumulation of pyrene and fluoranthene did not. Based on water and injection exposure to B(a)P, it was predicted that tissue concentrations in excess of 300 μg/kg B(a)P would be accompanied by MFO induction in rainbow trout.

Original languageEnglish (US)
Pages (from-to)284-295
Number of pages12
JournalEnvironmental Research
Volume17
Issue number2
DOIs
StatePublished - Oct 1978

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