Hormone-induced enlargement of receptive fields in trigeminal mechanoreceptive neurons. II. possible mechanisms

David A. Bereiter, Larry R. Stanford, David J. Barker

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37 Scopus citations

Abstract

Several possible mechanisms to account for hormone-induced enlargement of receptive field areas of individual mechanoreceptive trigeminal neurons of the rat were investigated. Mechanoreceptor sensitivity was estimated by receptive field thresholds and showed no consistent change following systemic estrogen treatment. Alteration of the viscoelastic properties of skin was suggested as 10 days of estrogen treatment caused an acute epidermal hyperplasia (38.7%), but force-displacement measurements revealed no significant change in skin distensibility. Interestingly, both chemical (6-hydroxydopamine) and surgical sympathectomy mimicked the effect of estrogen on receptive field areas by promoting dramatic enlargement of individual neuronal fields without decreasing receptive field force thresholds. Among skin samples from estrogen, 6-hydroxydopamine and surgical sympathectomized animals, only 6-hydroxydopamine treatment caused any significant alteration in skin norepinephrine content. These results strongly suggest an indirect catecholamine involvement in estrogen-induced enlargement of receptive field areas.

Original languageEnglish (US)
Pages (from-to)411-423
Number of pages13
JournalBrain Research
Volume184
Issue number2
DOIs
StatePublished - Feb 24 1980

Bibliographical note

Funding Information:
The authors wish to thank Mrs. D. Belosky for her assistance throughout the project, Dr. V. D. Ramirez for assistance with the catecholamine assays, and Mrs. C. McVeigh (Geneva, Switzerland) for the preparation of the final manuscript. This project was supported by N.I.H. Training Grant GM 619. D.A.B. was supported by a Predoctoral Traineeship, N.1.H. Training Grant GM 619.

Keywords

  • hormones
  • receptive field enlargement
  • sympathectomy
  • trigeminal mechanoreceptors

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