Host intestinal epithelial response to Cryptosporidium parvum

Mingqi Deng, Mark S. Rutherford, Mitchell S. Abrahamsen

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Cryptosporidium parvum is an obligate intracellular protozoan parasite that is a well-recognized cause of diarrhea in humans and animals throughout the world, and is associated with a substantial degree of morbidity and mortality in patients with the acquired immunodeficiency syndrome (AIDS). C. parvum primarily infects epithelial cells of the gastrointestinal tract, resulting in acute watery diarrhea for which there is no effective therapy. During infection, all parasite development, sexual or asexual, occurs within epithelial cells of the host. This requires a unique and complex association between two distinct eukaryotic organisms. Conversely, due to the intracellular nature of C. parvum, epithelial cells appear to play a key role in activating and communicating with the host immune system. Delineation of the biochemical processes that are regulated within infected epithelial cells is crucial for understanding the pathology of C. parvum infection, the process by which the host clears and ultimately develops resistance to infection, and the development of chemotherapeutic strategies to intercede infections.

Original languageEnglish (US)
Pages (from-to)869-884
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume56
Issue number6
DOIs
StatePublished - Apr 19 2004

Keywords

  • Cryptosporidium parvum
  • Gene expression
  • Intestinal epithelial cells
  • Microarray analysis
  • Mucosal immune response

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